The various health benefits of Trichopus zeylanicus leaves, investigated through scientific studies, are detailed below:
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Antifatigue and Stamina Enhancement:
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Traditional Use: Historically, Trichopus zeylanicus has been recognized as a rapid energy booster and for its ability to combat fatigue. The Kani tribes specifically claim that consuming the plant enables them to sustain prolonged physical labor.Ā Ā
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Scientific Evidence: Scientific investigations have confirmed its antifatigue and stamina-boosting properties. Studies conducted on Sprague-Dawley rats and Ames dwarf mice demonstrated thatĀ Ā Ā
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T. zeylanicus significantly extended swim time in forced swim tests, indicating an increased resistance to fatigue. Methanol and acetone extracts of the plant also improved swimming performance in mice. Notably, research indicates thatĀ Ā Ā
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Trichopus zeylanicus combats fatigue without exhibiting amphetamine-mimetic activity, suggesting a distinct and potentially safer mechanism of action.Ā Ā
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Adaptogenic and Anti-stress Properties:
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Traditional Use: The plant is recognized as an adaptogen, assisting the body in coping with physical and mental stressors.Ā Ā
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Scientific Evidence: Studies in rats and mice, utilizing various stress models, have revealed potent anti-stress properties. A glyco-peptido-lipid fraction derived from the alcoholic extract of the plant demonstrated significant anti-stress activity in a dose-dependent manner, enhancing the capacity of experimental animals to tolerate non-specific stress.Ā Ā
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Immunomodulatory Effects:
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Traditional Use/Claim: Trichopus zeylanicus is traditionally believed to stimulate and boost the immune system.Ā Ā
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Scientific Evidence: The plant has been identified as immunoenhancing. An alkaloid fraction ofĀ Ā Ā
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T. zeylanicus increased neutrophil adhesion and potentiated delayed type hypersensitivity reactions in mice. It also significantly elevated hematological parameters, including total white blood cells, red blood cells, and hemoglobin. Furthermore, it prevented myelosuppression in cyclophosphamide-treated mice. Oral administration in mice led to an increase in thymocytes, splenic lymphocytes, total blood leukocytes, and peritoneal macrophages. Additionally, it inhibited antigen-induced degranulation of sensitized mast cells in both mice and rats.Ā Ā
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Aphrodisiac Activity:
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Traditional Use/Claim: The plant is traditionally used to enhance sex drive and address sexual performance issues.Ā Ā
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Scientific Evidence: Animal research suggests a potential to increase sex drive. An ethanol extract ofĀ Ā Ā
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T. zeylanicus leaf stimulated sexual behavior in male mice, leading to increased mounts and mating performance in a concentration-dependent manner.Ā Ā
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Hepatoprotective (Liver Protective) Actions:
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Traditional Use/Claim: Trichopus zeylanicus is traditionally used to treat liver disease.Ā Ā
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Scientific Evidence: Alcoholic extracts derived from the seed, leaf, and rhizome of the plant demonstrated potent hepatoprotective activity across various experimental models. A methanol extract exhibited remarkable hepatoprotective activity against paracetamol-induced hepatotoxicity in rats and also showed choleretic activity. It has also been shown to ameliorate ibuprofen-induced hepatotoxicity.Ā Ā
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Antioxidant and DNA Protecting Capabilities:
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Mechanism: The antioxidant compounds present in the plant are believed to neutralize free radicals, thereby mitigating oxidative damage and promoting cellular health.Ā Ā
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Scientific Evidence: T. zeylanicus extract enhanced the antioxidant status in liver mitochondria of aged mice, evidenced by higher levels of GSH, increased activity of Superoxide Dismutase (SOD) and Catalase (CAT), and decreased Malondialdehyde (MDA). It exhibited significant radical scavenging activities and inhibited lipid peroxidation and reactive oxygen species-induced DNA damage. The plant contains NADH, polyphenols, and sulfhydryl compounds, which are known for their ability to scavenge reactive oxygen species.Ā
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